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However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response.

This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing NGS data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response.

Molecular Determinants of Head and Neck Cancer

It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Mol Cancer Ther.


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  • Molecular Determinants of Head and Neck Cancer | SpringerLink.
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TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res.

Molecular Determinants of Head and Neck Cancer by Barbara Burtness 9783319787619

Epub Nov Individualizing anti-metabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status. Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer , Jul 1; 13 Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content. Ow, M. Faculty Profile.

Thomas J. Hardcover Humana.

Burtness / Golemis | Molecular Determinants of Head and Neck Cancer | 2nd ed. |

For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer.


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However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response.

This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome.